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Related Concept Videos

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

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Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though pharmacologically...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Related Experiment Video

Updated: Jul 1, 2026

Preparation and Characterization of SDF-1&#945;-Chitosan-Dextran Sulfate Nanoparticles
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Chitosan-based formulations for therapeutic applications. A recent overview.

Weronika Gonciarz1, Ewa Balcerczak2,3, Marek Brzeziński4

  • 1Department of Immunology and Infectious Biology, Institute of Microbiology, Biotechnology, and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237, Lodz, Poland. weronika.gonciarz@biol.uni.lodz.pl.

Journal of Biomedical Science
|July 8, 2025
PubMed
Summary

Chitosan, a natural polymer, offers unique properties for biomedical uses. This review details its applications in treating diseases and in regenerative medicine, highlighting its potential in advanced biomaterials.

Keywords:
Biomedical applicationsChitosanMicroparticlesNanoparticles

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry

Background:

  • Chitosan is a natural cationic polymer derived from chitin.
  • It exhibits valuable physicochemical, biological, and ecological properties, including biocompatibility, biodegradability, and non-toxicity.
  • These characteristics make it suitable for diverse biomedical and industrial applications.

Purpose of the Study:

  • To review recent advancements in chitosan-based formulations for therapeutic applications.
  • To explore the use of chitosan-derived biomaterials in regenerative medicine and food packaging.

Main Methods:

  • Literature review of recent developments in chitosan-based biomaterials.
  • Focus on applications in disease treatment and material science.

Main Results:

  • Chitosan formulations show promise in treating bacterial and viral infections, cancer, and gastroesophageal reflux disease.
  • Chitosan-derived materials are effective in regenerative medicine and preventing food contamination.

Conclusions:

  • Chitosan is a versatile biomaterial with significant potential in various biomedical fields.
  • Further research in chitosan-based applications is warranted for emerging technologies.