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Principles Of Column Chromatography01:13

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The chromatography technique was first invented in 1901 by Michael S. Tswett, a Russian botanist, to separate plant pigments using organic solvents. Further, in 1941, Archer John Porter Martin and R. L. M. Synge modified the technique by packing silica gel into a column. A mixture of amino acids was then separated on the packed column using chloroform and water mixture as the mobile phase. This was the first report on column chromatography. At present, column chromatography is a widely used...
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Author Spotlight: Eco-friendly Photoluminescent Textile Authentication with Curcumin
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Revolutionizing Curcumin Extraction: New Insights From Non-Conventional Methods-A Comparative Analysis of the Last

Isabelle O Torquato1, Astrid Corrales1, Cassamo U Mussagy2

  • 1Bioseparations and Nanoformulations Lab, Department of Biotechnology, Lorena School of Engineering, University of São Paulo (EEL/USP), Lorena, São Paulo, Brazil.

Journal of Separation Science
|July 9, 2025
PubMed
Summary

This review highlights sustainable methods for extracting curcumin (CCM) from Curcuma longa. It compares conventional and eco-friendly techniques, emphasizing green solvents for improved yield and reduced environmental impact.

Keywords:
curcuminoidseco‐friendlyenvironmental sustainabilitypurificationseparationsolvents

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Area of Science:

  • Phytochemistry
  • Green Chemistry
  • Biotechnology

Background:

  • Curcumin (CCM), derived from Curcuma longa L. rhizomes, possesses significant pharmaceutical and biotechnological potential.
  • Extraction of CCM is crucial, yet existing reviews lack a comparative analysis of improved extraction methods.
  • Conventional methods often use volatile organic compounds, leading to low yields, long extraction times, and environmental concerns.

Purpose of the Study:

  • To identify and compare efficient, sustainable extraction methods for Curcumin (CCM).
  • To discuss the integration of advanced extraction techniques with green solvents.
  • To address the gap in comparative analysis of CCM extraction process improvements.

Main Methods:

  • Review of conventional solid-liquid extraction methods.
  • Analysis of non-conventional, eco-friendly methods: ultrasound-assisted, microwave-assisted, enzyme-assisted, and supercritical fluid extraction.
  • Evaluation of solvent selection, focusing on sustainable and neoteric solvents.

Main Results:

  • Conventional methods exhibit limitations including low yields, prolonged times, and environmental impact.
  • Non-conventional methods, especially when paired with green solvents, offer enhanced efficiency, selectivity, and environmental benefits.
  • Optimal combination of extraction techniques and solvents is key to maximizing CCM recovery.

Conclusions:

  • Innovative, eco-friendly extraction methods combined with sustainable solvents are essential for efficient CCM production.
  • Future research should focus on optimizing and integrating these methods for improved yield, reduced environmental footprint, and scalability.
  • This approach aligns with sustainable practices in bioindustries.