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Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
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Causal relationship between primary biliary cholangitis on osteoporosis: A two-sample Mendelian randomization study.

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Primary biliary cholangitis (PBC) may increase the risk of osteoporosis (OP). This Mendelian randomization study found a significant association, suggesting PBC is a risk factor for OP development.

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Area of Science:

  • Gastroenterology and Hepatology
  • Endocrinology and Metabolism
  • Genetic Epidemiology

Background:

  • Primary biliary cholangitis (PBC) is a chronic liver disease with potential systemic complications.
  • Osteoporosis (OP) is characterized by reduced bone mass and increased fracture risk.
  • The relationship between PBC and OP requires further elucidation.

Purpose of the Study:

  • To investigate the causal relationship between primary biliary cholangitis (PBC) and osteoporosis (OP).
  • To utilize a two-sample Mendelian randomization (MR) approach to assess this association.
  • To explore potential genetic links between PBC and OP.

Main Methods:

  • A two-sample Mendelian randomization (MR) analysis was performed.
  • Inverse variance weighted (IVW) method was used for primary causal estimation.
  • MR-Egger regression, MR-PRESSO, Cochran Q test, and leave-one-out analysis were employed for sensitivity analyses and pleiotropy assessment.

Main Results:

  • A significant positive association was found between PBC and OP (OR = 1.098, P = 5.41e-05).
  • Sensitivity analyses indicated no significant horizontal pleiotropy (MR-Egger P = 0.754) or heterogeneity (Cochran Q P = 0.236).
  • Leave-one-out analysis confirmed the robustness of the findings.

Conclusions:

  • The study provides genetic evidence supporting a causal link between primary biliary cholangitis and an increased risk of osteoporosis.
  • These findings contribute to understanding the systemic effects of PBC and highlight potential shared pathways.
  • Further research may explore therapeutic strategies targeting bone health in PBC patients.