Animal models of psoriasis for novel drug discovery: a literature update
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Summary
This summary is machine-generated.This review evaluates preclinical psoriasis models, finding no single system perfectly mimics the human condition. Combining complementary models and advanced techniques like CRISPR/Cas9 is crucial for future therapeutic development in psoriasis research.
Area Of Science
- Dermatology and immunology research focusing on preclinical models for psoriasis.
Background
- Psoriasis is a chronic, immune-mediated inflammatory skin disease with complex pathogenesis.
- Effective therapeutics depend on preclinical models that accurately replicate disease mechanisms.
Purpose Of The Study
- To review and evaluate current in vivo psoriasis models.
- To assess the utility of gene editing technologies in model development.
- To highlight limitations and future directions for psoriasis research models.
Main Methods
- Comprehensive literature search of PubMed, Scopus, and Google Scholar (Jan 2015-Mar 2025).
- Evaluation of spontaneous mutation, transgenic, knockout, xenotransplantation, cytokine-induced, and imiquimod-induced models.
- Assessment of CRISPR/Cas9 gene editing applications in creating targeted psoriasis models.
Main Results
- No single in vivo model fully replicates human psoriasis.
- Imiquimod-induced models are practical but better represent acute inflammation.
- Key histological and immunological features of psoriasis are variably reproduced across models.
Conclusions
- Multimodel validation strategies are essential for translational relevance.
- Humanized systems and genome editing advancements hold promise for future research.
- Combining complementary models and human-derived components can enhance translational applicability.
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