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An Automated T-maze Based Apparatus and Protocol for Analyzing Delay- and Effort-based Decision Making in Free Moving Rodents
Published on: August 2, 2018
[Neural Mechanisms of the Nucleus Accumbens for Flexible and Strategic Decision-Making]
1Laboratory for Advanced Brain Functions, Institute for Protein Research, The University of Osaka.
Abstract:
Decision-making requires flexibility and strategy. Imaging of single-cell-level neural activity and inhibition of neural activity in mice during a visual-discrimination learning task that requires a strategy revealed that dopamine D2 receptor-expressing medium-sized spiny neurons in the nucleus accumbens are important for flexible and strategic decision-making. Single-cell level imaging may be useful in understanding the pathophysiology of neuropsychiatric disorders that impair decision-making flexibility.
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