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Carnitine: Its Crucial Role in Metabolic Health and Cardiovascular Function
Fremita Fredrick1, Kanishk Aggarwal2, Anish Kumar Reddy Meda1
1Avalon University School of Medicine, Willemstad, Curacao.
Journal of Dietary Supplements
|July 9, 2025
Summary
Carnitine supplementation shows promise for improving cardiovascular health by aiding fatty acid metabolism and energy production. However, potential risks like elevated trimethylamine-N-oxide require further investigation.
Area of Science:
- Biochemistry
- Cardiology
- Nutritional Science
Background:
- Carnitine, an amino acid derivative, is crucial for fatty acid metabolism and energy production.
- It facilitates the transport of long-chain fatty acids into mitochondria for beta-oxidation, essential for ATP synthesis.
Purpose of the Study:
- To explore the effects of carnitine supplementation on cardiovascular health.
- To review its pathophysiology and clinical applications in cardiovascular conditions.
Main Methods:
- Literature review of studies on carnitine supplementation and cardiovascular outcomes.
- Analysis of evidence regarding carnitine's role in cardiac function, metabolic profiles, and potential adverse effects.
Main Results:
- Carnitine supplementation may improve cardiac function and reduce heart failure biomarkers.
- Evidence suggests benefits in conditions like chronic heart failure and myocardial infarction.
- Concerns exist regarding potential increases in trimethylamine-N-oxide and atherosclerotic markers.
Conclusions:
- Carnitine supplementation presents a potential therapeutic strategy for cardiovascular diseases.
- Further research is needed to balance benefits against potential risks, particularly concerning TMAO levels.
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