[Complement fixation activity of immunoglobulin G in ethylene glycol solutions]

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Updated: Oct 23, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

S Iu Tétin, K A Efetov, G V Troitskiĭ

    Bioorganicheskaia Khimiia
    |August 1, 1985
    PubMed

    Affinity of IgG to the first complement factor C1q was found out to increase in 10-30% glycol solutions. Analytical ultracentrifugation and turbidity data showed that IgG molecules do not aggregate at such concentrations of glycol. The complement-binding effect may be caused by a conformational transition in the IgG molecules.

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