Response to Adler and Parmryd

The Pearson Correlation Coefficient can be calculated using three different criteria for pixel selection. These criteria carry different implications for interpretation of the metric. Different image analysis tools use these different criteria, and it is important that users know which criteria they have used. We maintain that this is important information for the community to consider and that we accurately addressed this topic. Adler and Parmryd have identified a flaw in our analysis in Figure 2 and here we explain how this came about and provide a correction. Alder and Parmryd's letter maligns our intent and competency - we refute all accusations and we object to the use of ad hominem arguments in scientific discourse.