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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease II: Clinical Manifestations01:24

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
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Related Experiment Video

Updated: Sep 16, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Gut Microbiome as a Risk Factor for Future CKD.

Tapio Hellman1, Li-Fang Yeo2,3, Joonatan Palmu2,3,4

  • 1Kidney Center, Turku University Hospital and University of Turku, Turku, Finland.

Kidney International Reports
|July 9, 2025
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Summary

Lower gut microbial diversity is linked to increased risk of developing chronic kidney disease (CKD). This study suggests a potential role for the Lachnospiraceae family in maintaining kidney health.

Keywords:
chronic kidney diseaseclinical studymicrobiologyproteinuria

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Area of Science:

  • Microbiome research
  • Nephrology
  • Public health

Background:

  • The gut microbiome's association with chronic kidney disease (CKD) is suggested by small studies.
  • Long-term relationships between gut microbiome composition and incident CKD are not well-established.

Purpose of the Study:

  • To investigate the association between baseline gut microbiome and long-term incident CKD.
  • To explore links between gut metagenome, serum creatinine (SCR), and urine albumin-to-creatinine ratio (UACR).

Main Methods:

  • Fecal sampling and measurements of SCR and UACR in a population-based cohort (N=6699 for SCR, N=797 for UACR).
  • Assessment of multivariable-adjusted associations between gut metagenome and baseline SCR, UACR, and incident CKD over a median follow-up of 18.6 years.

Main Results:

  • Increased gut microbiome alpha diversity was associated with a lower risk of incident CKD (HR per 1 SD: 0.84; P=0.04).
  • Alpha and beta diversity were associated with baseline SCR, but not UACR.
  • 43 species-level associations with SCR were found, including negative associations with Lachnospiraceae family members.

Conclusions:

  • Decreased gut microbial diversity may predict future CKD risk.
  • A potential link exists between the Lachnospiraceae family and kidney health, warranting further investigation.