Ipso nitration in organic synthesis
Hassan Sepehrmansourie1, Mahmoud Zarei2, Shadpour Mallakpour3
1Faculty of Converging Science and Technologies, University of Qom Qom 37185-359 Iran sepehr9129@yahoo.com.
Abstract:
Ipso reaction is a class of nitration reactions that involve the concerted movement of multiple atoms in a transition state. Nitro structures are vital intermediates in synthetic organic chemistry and related industries. This method has been introduced in the preparation of NO2-containing structures with a wide range of leaving groups such as -B(OH)2, -CO2H, -SO3H, -OR, -R, -X, -CHO, -COMe, -CO2Me, -MR3 and -BF3K. Ipso nitration reactions have an essential impact on the synthesis of complex organic molecules and have been widely studied and utilized in organic chemistry. This review provides a comprehensive overview of the fundamental concepts and mechanisms underlying ipso reactions, highlighting their significance in contemporary organic chemistry.
Related Concept Videos
Electrophilic Aromatic Substitution: Nitration of Benzene
Preparation of Nitriles
Nitrosation of Enols
Preparation of Amines: Reduction of Oximes and Nitro Compounds
Though catalytic hydrogenation can reduce nitrobenzenes, the reduction is nonselective in the presence of other functional groups. For instance, if nitrobenzene contains an aldehyde group,...
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Overview
The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by...
1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism

![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
