Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Risk Factors and Outcomes of Premature Rupture of Membranes Among Women in the Middle East and North Africa: Mapping Review.

Journal of clinical medicine·2026

Same author

[Remodelling of the lamina cribrosa of the sclera in optic nerve axonal injury].

Vestnik oftalmologii·2026

Same author

AI-mediated risks and real-life challenges in mushroom foraging.

NPJ science of food·2026

Same author

Emotional Functioning as a Dimension of Quality of Life in Breast Cancer Survivors: A Systematic Review and Meta-Analysis.

Cancers·2025

Same author

Microgravity Impacts the Expression of Aging-Associated Candidate Gene Targets in the p53 Regulatory Network.

International journal of molecular sciences·2025

Same author

The Emerging Role of Phosphodiesterase Inhibitors in Fragile X Syndrome and Autism Spectrum Disorder.

Pharmaceuticals (Basel, Switzerland)·2025

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Published on: November 17, 2014

Individual Risk Assessment and Prognostication of Outcomes After Corneal Cross-Linking.

Y Statsenko^1,2, K Liaonchyk³, D Morozova³

¹Imaging Platform, ASPIRE Precision Medicine Research Institute Abu Dhabi, Al Ain, UAE.

Journal of Ophthalmology

|July 9, 2025

Summary

Preoperative corneal measurements can predict the success of corneal collagen cross-linking (CXL) for keratoconus (KC). Thin corneas, poor vision, and high Kmax indicate less favorable CXL outcomes, guiding personalized treatment selection.

Keywords:

corneal collagen cross-linking explainable artificial intelligence intervention outcome keratoconus keratometry readings machine learning precision medicine predictive model

More Related Videos

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

Related Experiment Videos

Last Updated: Jul 8, 2026

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Published on: November 17, 2014

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

Area of Science:

Ophthalmology
Biomedical Engineering
Corneal Science

Background:

Keratoconus (KC) is a progressive corneal disease.
Corneal collagen cross-linking (CXL) is a standard treatment to halt KC progression.
Patient responses to CXL vary significantly, necessitating predictive markers.

Purpose of the Study:

To identify preoperative diagnostic findings that predict the efficacy of CXL in keratoconus patients.
To develop models for prognostication of CXL treatment outcomes.
To enable personalized selection of candidates for CXL therapy.

Main Methods:

Retrospective analysis of 107 patients (112 eyes) treated with CXL.
Inclusion of preoperative and postoperative data including clinical assessment, pachymetry, visiometry, refractometry, and topography.
Modeling of maximum anterior keratometry (Kmax) and corneal curvature coefficients (K1, K2).

Main Results:

Corneal curvature coefficients showed a progressive decrease post-CXL, stabilizing, then rising.
Models for K1, K2, and Kmax demonstrated high accuracy with low mean absolute errors (1.72%, 3.66%, 2.37%).
Pronounced corneal thinning, low best-corrected visual acuity, and high Kmax levels were associated with unfavorable outcomes.

Conclusions:

Preoperative diagnostic findings, particularly corneal thinning, visual acuity, and Kmax, are accurate predictors of CXL outcomes.
Developed models support personalized patient selection for CXL.
Accurate prognostication can optimize CXL treatment strategies for keratoconus.