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Updated: May 12, 2026
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Role of TERT gene mutation in the pathogenesis of anaplastic thyroid carcinoma (Review)
Abdul-Mohsen G Alhejaily1, Omar Alhuzaim2,3, Naji Aljohani2,3
1Academic Operations Administration, King Fahad Medical City, Riyadh Second Health Cluster, Riyadh 11525, Kingdom of Saudi Arabia.
Abstract:
The present review provides a comprehensive analysis of the significance of telomerase reverse transcriptase (TERT) promoter mutations in the progression of anaplastic thyroid cancer (ATC). The significance of these mutations lies in their role in reactivating telomerase, and when combined with BRAF and RAS mutations, they contribute to heightened aggressiveness in ATC. The clinical implications of TERT promoter mutations were discussed, evaluating their potential role as prognostic biomarkers and targets for therapeutic intervention. The present review also emphasizes recent developments in our comprehension of TERT's role in the progression of ATC, offering insights that may guide future investigations focused on improving patient management for this condition.
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