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Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...

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Related Experiment Video

Updated: Sep 16, 2025

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

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Published on: August 18, 2020

Cannabidiol Induced Manic Episode: A Case Report.

Anas Ibn Auf¹, Razan A Almakki², Nora M Alhummayani³

¹Auf, Erada and mental health complex, Taif, Saudi Arabia; Department of Psychiatry, Eastern Sudan University for Medical Sciences and Technology, Port Sudan, Sudan.

Psychopharmacology Bulletin

|July 9, 2025

Summary

High-dose cannabidiol (CBD) may trigger manic episodes in susceptible individuals, challenging its perceived safety. Further research is needed to understand CBD

Keywords:

adverse drug reaction reporting systems bipolar disorder cannabidiol mood disorders substance-related disorders

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Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Cannabidiol (CBD), a non-intoxicating Cannabis sativa compound, is popular for proposed therapeutic benefits.
CBD is often considered safe with minimal psychoactive effects, unlike THC.
The psychiatric safety profile of CBD, especially for mood disorders, requires further investigation.

Observation:

A 31-year-old male with no prior psychiatric history developed mania after three months of escalating daily CBD vaping.
Symptoms included irritability, reduced sleep, hyperactivity, and aggression.
Toxicology was negative for other substances; symptoms improved after CBD cessation and treatment.

Findings:

High-dose CBD use may induce manic symptoms in some individuals.
CBD's effect on mood regulation appears complex and potentially dose-dependent.
Product variability and contamination in commercial CBD products complicate safety assessments.

Implications:

Clinicians should monitor for psychiatric effects of CBD, especially new-onset mood symptoms.
Controlled studies are essential to evaluate CBD safety in psychiatric populations.
Stricter regulation of cannabinoid products is necessary.