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Related Concept Videos

Nociception01:44

Nociception

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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Optimizing Photoneuromodulation Techniques to Evaluate the Role of Green Light-Emitting Diodes in Pain Management
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Highly-Sensitive Implantable NIR Phototransistor for One-Click Pain Relief Activation.

Lingxuan Jia1,2, Lei Shi3,4,5, Zhiyi Li1

  • 1Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.

Advanced Materials (Deerfield Beach, Fla.)
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Summary

Researchers developed implantable near-infrared pain relief controllers using stretchable organic phototransistors. This technology offers rapid, on-demand inhibition of nerve signals, achieving 99.4% pain signal suppression in rats within 20 milliseconds.

Keywords:
electrical nerve stimulationimplantable devicesorganic phototransistorpain relief

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neuroscience

Background:

  • Chronic neuralgic pain is a growing health concern, necessitating advanced pain management solutions.
  • Current pain relief technologies face challenges in providing on-demand nerve signal inhibition due to the sporadic nature of pain.

Purpose of the Study:

  • To develop and demonstrate an implantable pain relief controller utilizing near-infrared (NIR) technology.
  • To achieve precise, on-demand inhibition of nerve transduction for effective pain management.

Main Methods:

  • Fabrication of implantable controllers with stretchable organic phototransistors (IDTBT/Y6 bulk-heterojunction).
  • Integration of phototransistors with an oscillating circuit for NIR-triggered voltage modulation (1 kHz to 50 kHz).
  • In vivo testing on rat sciatic nerves to measure neural signal suppression and pain reflex reduction.

Main Results:

  • The phototransistors exhibited high responsiveness and detectivity (up to 9.4 × 10^13 Jones).
  • NIR irradiation effectively triggered voltage changes, enabling precise neural activity manipulation.
  • Achieved up to 99.4% suppression of neural signals within 20 milliseconds in rat models.
  • Confirmed near real-time pain sensation elimination through reduced hind paw reflex movements.

Conclusions:

  • The developed NIR pain relief controller offers a novel and effective approach for on-demand pain management.
  • This technology demonstrates potential for advanced medical applications in treating chronic neuralgic pain.
  • The system provides precise, rapid, and highly efficient inhibition of nerve transduction.