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Updated: Sep 16, 2025

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Augmented 3D Printing for Multiscale Microphysiological Systems.

Kyeong Seob Hwang1,2, Jiyoung Song1, Hyun Wook Kang3

  • 1Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.

Small (Weinheim an Der Bergstrasse, Germany)
|July 9, 2025
PubMed
Summary

Augmented 3D printing integrates multiscale techniques to overcome limitations in fabricating complex microphysiological systems (MPS). This approach enables the creation of more physiologically relevant MPS for advanced tissue engineering applications.

Keywords:
3D printingaugmented 3D printingmicrophysiological systemmultiscale ancillary techniques

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Area of Science:

  • Biomedical Engineering
  • Tissue Engineering
  • Materials Science

Background:

  • Microphysiological systems (MPS) mimic human organ functions but face fabrication challenges.
  • Current engineering techniques limit the sophistication and functionality of MPS.
  • Existing 3D-printed MPS struggle with fabricating multiscale structures (nanometers to centimeters).

Purpose of the Study:

  • To review augmented 3D-printing techniques for multiscale MPS fabrication.
  • To highlight recent advancements in augmented 3D-printed MPS.
  • To demonstrate the potential of augmented 3D printing in next-generation tissue engineering.

Main Methods:

  • Overview of 3D-printing methods.
  • Integration of multiscale ancillary techniques with 3D printing.
  • Review of recent developments in augmented 3D-printed MPS.

Main Results:

  • Augmented 3D printing addresses limitations in multiscale MPS fabrication.
  • New techniques enable the creation of MPS with enhanced complexity and functionality.
  • Augmented 3D-printed MPS surpass conventional system features.

Conclusions:

  • Augmented 3D printing represents a significant advancement in tissue engineering.
  • This approach facilitates the development of MPS with more physiologically relevant structures and functions.
  • It paves the way for next-generation tissue engineering solutions.