Gastrointestinal diffuse large B-cell lymphoma: Clinical characteristics and prognostic analysis from SEER database

Area of Science:

• Oncology
• Hematology
• Epidemiology

Background:

• Gastrointestinal diffuse large B-cell lymphoma (GI-DLBCL) is a significant hematologic malignancy.
• Accurate prognostic assessment is crucial for effective GI-DLBCL patient management.

Purpose of the Study:

• To systematically analyze clinicopathological characteristics and prognostic factors of GI-DLBCL patients.
• To develop and validate a predictive nomogram model for GI-DLBCL prognosis.

Main Methods:

• Utilized the SEER database for a large-scale retrospective analysis.
• Employed Kaplan-Meier, LASSO regression, and Cox regression for survival and variable analysis.
• Constructed and validated a nomogram incorporating independent prognostic factors.

Main Results:

• Identified age >60, advanced Ann Arbor stage, and widowed status as independent poor prognostic factors.
• Chemotherapy, radiotherapy, surgery, and lymph node resection demonstrated survival benefits.
• The developed nomogram achieved a C-index of 0.71, outperforming the Ann Arbor staging system (C-index=0.56).

Conclusions:

• The novel nomogram model provides a robust and validated tool for predicting GI-DLBCL patient prognosis.
• This model facilitates individualized treatment decisions and improves clinical management of GI-DLBCL.
• The study highlights the importance of integrating multiple factors for accurate GI-DLBCL outcome prediction.