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Association between high-sensitivity C-reactive protein, cystatin C and all-cause mortality in middle-aged and
Yunteng Fang1,2, XiaoYan Wu2, Jiayi Shen1,2
1Zhejiang University Lishui Hospital, Lishui, China.
Insights
Elevated high-sensitivity C-reactive protein (hs-CRP) and cystatin C (CysC) levels are linked to increased all-cause mortality in older adults with sarcopenia. Combining these biomarkers may improve mortality prediction in this population.
Area of Science:
- Gerontology
- Biomarker Research
- Clinical Medicine
Background:
- High-sensitivity C-reactive protein (hs-CRP) and cystatin C (CysC) are established prognostic indicators for inflammation and kidney function.
- Their association with mortality in individuals with sarcopenia remains an area of investigation.
Purpose of the Study:
- To investigate the relationship between elevated hs-CRP and CysC concentrations and all-cause mortality in middle-aged and elderly individuals diagnosed with sarcopenia.
- To assess the combined prognostic value of hs-CRP and CysC for mortality prediction in this cohort.
Main Methods:
- Retrospective analysis of 612 Chinese individuals with sarcopenia.
- hs-CRP and CysC levels categorized into tertiles; Cox regression models used to determine hazard ratios (HR) and 95% confidence intervals (CI).
- Combined effects analyzed by grouping participants based on high-risk cutoffs for both biomarkers; subgroup analyses conducted.
Main Results:
- A total of 130 deaths occurred during follow-up, yielding a mortality rate of 21.2%.
- Both hs-CRP and CysC showed significant associations with all-cause mortality as continuous variables; hs-CRP also predicted mortality categorically.
- The combination of elevated hs-CRP and CysC demonstrated a significant positive association with mortality (HR=2.26, 95%CI: 1.01-5.07 in Model 3), particularly in males aged over 75.
Conclusions:
- hs-CRP and CysC show potential as useful prognostic indicators for middle-aged and elderly individuals with sarcopenia.
- The combined assessment of hs-CRP and CysC effectively predicts mortality risk in this population.
Background:
High-sensitivity C-reactive protein (hs-CRP) and cystatin C (CysC), which associate with prognosis, are widely used indicators for inflammation and kidney function respectively in clinical practice.
Aims:
This study aims to determine whether elevated hs-CRP and CysC concentrations are associated with all-cause mortality in middle-aged and elderly participants with sarcopenia.
Methods:
This was a retrospective study which included 612 individuals with sarcopenia from a Chinese cohort. Concentrations of hs-CRP and CysC were divided into three groups (tertiles). Cox regression models were utilized to estimate hazard ratios (HR) and 95% confidence intervals (CI) for all-cause mortality. Combined effects were calculated by dividing two indicators into four groups based on cutoffs of high risk. Subgroup analyses were performed to better stratify analyses and show the interaction of variables for associations between hs-CRP/CysC and mortality.
Results:
The mean age of the participants was 70.88 (6.61) years, among which 40.03% were male. During follow-up 130 death cases occurred and mortality rate was 21.2%. Hs-CRP and CysC were prominently associated with all-cause mortality as continuous variables. Hs-CRP also manifested great capability of predicting mortality as categorical variable. When both indicators were higher than cutoffs, the combined effect was positive in Model3 (HR = 2.26, 95%CI: 1.01-5.07). Two biomarkers showed significant associations among subgroup population who were male and > 75 years old. CysC had an linear association with mortality while hs-CRP not.
Conclusion:
Hs-CRP and CysC might be useful indicators for the prognosis of middle-aged and elderly participants with sarcopenia. The combined effects of two indicators predicted mortality well.
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