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Cardiac Involvement in Eosinophilic Granulomatosis with Polyangiitis
Mukunthan Srikantharajah1,2, Deepa Gopalan3,4, Harold Wilson-Morkeh5,6
1Vasculitis Centre, Department of Immunology and Inflammation, Imperial College London, London, UK.
Current Cardiology Reports
|July 9, 2025
Summary
Cardiac disease significantly impacts patients with Eosinophilic granulomatosis with polyangiitis (EGPA), causing approximately 50% of deaths. Early diagnosis using cardiac magnetic resonance (CMR) is crucial for timely treatment and improved outcomes.
Area of Science:
- Cardiology
- Rheumatology
- Immunology
Background:
- Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis.
- Cardiac involvement is a leading cause of mortality in EGPA patients.
- Current diagnostic criteria for cardiac disease in EGPA are not standardized.
Purpose of the Study:
- To review recent advancements in understanding cardiac disease in EGPA.
- To outline a diagnostic approach for early identification of cardiac involvement.
- To emphasize the importance of cardiac assessment in EGPA management.
Main Methods:
- Review of recent literature on EGPA and cardiac disease.
- Highlighting the role of cardiac magnetic resonance (CMR) in diagnosis.
- Discussion of diagnostic challenges and proposed strategies.
Main Results:
- CMR can detect cardiac abnormalities in EGPA patients, even those asymptomatic.
- Cardiac disease is prevalent and a major contributor to mortality in EGPA.
- Systemic immunosuppressive therapy is essential for managing cardiac complications.
Conclusions:
- Early detection of cardiac disease in EGPA is critical.
- Cardiac magnetic resonance (CMR) should be part of the baseline evaluation for all EGPA patients.
- Prompt immunosuppressive therapy can mitigate acute and long-term cardiac damage.
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