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Cardiac Involvement in Eosinophilic Granulomatosis with Polyangiitis

Mukunthan Srikantharajah1,2, Deepa Gopalan3,4, Harold Wilson-Morkeh5,6

  • 1Vasculitis Centre, Department of Immunology and Inflammation, Imperial College London, London, UK.

Current Cardiology Reports
|July 9, 2025
PubMed

Insights

Cardiac disease significantly impacts patients with Eosinophilic granulomatosis with polyangiitis (EGPA), causing approximately 50% of deaths. Early diagnosis using cardiac magnetic resonance (CMR) is crucial for timely treatment and improved outcomes.

Area of Science:

  • Cardiology
  • Rheumatology
  • Immunology

Background:

  • Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis.
  • Cardiac involvement is a leading cause of mortality in EGPA patients.
  • Current diagnostic criteria for cardiac disease in EGPA are not standardized.

Purpose of the Study:

  • To review recent advancements in understanding cardiac disease in EGPA.
  • To outline a diagnostic approach for early identification of cardiac involvement.
  • To emphasize the importance of cardiac assessment in EGPA management.

Main Methods:

  • Review of recent literature on EGPA and cardiac disease.
  • Highlighting the role of cardiac magnetic resonance (CMR) in diagnosis.
  • Discussion of diagnostic challenges and proposed strategies.

Main Results:

  • CMR can detect cardiac abnormalities in EGPA patients, even those asymptomatic.
  • Cardiac disease is prevalent and a major contributor to mortality in EGPA.
  • Systemic immunosuppressive therapy is essential for managing cardiac complications.

Conclusions:

  • Early detection of cardiac disease in EGPA is critical.
  • Cardiac magnetic resonance (CMR) should be part of the baseline evaluation for all EGPA patients.
  • Prompt immunosuppressive therapy can mitigate acute and long-term cardiac damage.
Abstract

Keywords:
Cardiac magnetic resonanceCardiovascularEosinophilic granulomatosis with polyangiitisVasculitis

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