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Sleep Disturbances in Survivors of Childhood Acute Lymphoblastic Leukemia: A Cross-Sectional Study

Kanwaljeet Kaur Chopra1, Aditya Kumar Gupta2, Jagdish Prasad Meena1

  • 1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Indian Pediatrics
|July 9, 2025
PubMed

Insights

Pediatric acute lymphoblastic leukemia (ALL) survivors frequently experience sleep disturbances. Fears during chemotherapy and a shorter time since treatment completion are significant risk factors for these sleep problems.

Area of Science:

  • Pediatric Oncology
  • Sleep Medicine
  • Childhood Cancer Survivorship

Background:

  • Survivors of childhood cancer face a high risk of sleep disturbances, impacting their overall well-being.
  • Sleep issues in pediatric cancer survivors are often overlooked in holistic care approaches.

Purpose of the Study:

  • To determine the prevalence of sleep disturbances in survivors of childhood acute lymphoblastic leukemia (ALL).
  • To identify risk factors associated with sleep problems in this population.

Main Methods:

  • The study enrolled survivors of ALL aged 6-18 years, with treatment completed at least two years prior.
  • The Child Sleep Habits Questionnaire (CSHQ) was utilized to assess sleep problems.

Main Results:

  • Sleep disturbances were reported by 42.7% of the 89 childhood ALL survivors studied.
  • Factors significantly associated with sleep problems included treatment-related fears, painful memories, younger age at enrollment, and a shorter interval since treatment completion.

Conclusions:

  • Nearly half of childhood ALL survivors experience sleep problems.
  • Fears encountered during chemotherapy and a shorter post-treatment interval emerged as significant risk factors for sleep disturbances.
Abstract

Keywords:
CancerChildSleep disturbancesSurvivorship

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