Related Experiment Video
Updated: Sep 16, 2025

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
When and Under What Circumstances Does Neuroticism Change in the Unified Protocol?
Nicole E Stumpp1, Matthew W Southward2, Alexandra Hines1
1Clinic for Emotional Health, Department of Psychology, University of Kentucky, Lexington, KY, USA.
Method:
Seventy adult participants (Mage = 33.74, 67% female, 74% White) with an emotional disorder were randomized to (a) receive UP modules in an order that capitalized on their strengths, compensated for their deficits, or a standard order and (b) receive 6 or 12 sessions of treatment. We conducted piecewise hierarchical linear regression models to test if specific sequencing or duration conditions led to greater reductions in neuroticism.
Results:
Changes in neuroticism did not significantly differ between the treatment duration conditions over the first six sessions, however, those in the full treatment condition exhibited significantly greater reductions in neuroticism from weeks 7-12. When controlling for depressive and anxiety symptoms, there were no significant changes in neuroticism in the first six sessions. Those in the full treatment condition demonstrated significant reductions in neuroticism from sessions 7-12.
Conclusion:
Brief treatment may exhibit state-level changes in neuroticism, but a more extensive course may be needed for lasting trait change.
Related Concept Videos
Neuronal Communication
Panic Disorder
Functions of the Nervous System
Nervous System
Psychological Responses to Stress
Anxiety: Overview
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.

