Allergic manifestations of actinopathies: A review

Actinopathies are conditions that impact the maturation and formation of actin filaments. When actinopathies affect immune cells, immune dysregulation leads to atopic disease, autoimmunity, autoinflammation, and increased infection. Many actinopathies, including Wiskott-Aldrich syndrome and Dedicator of cytokinesis 8 (DOCK8) deficiency, have prominent atopic manifestations. With emerging research and new clinical descriptions of patients diagnosed with actinopathies, the impact of actinopathies on allergic pathways has expanded. Furthermore, effective treatments related to atopy have been identified in specific patient groups. Here, we review the literature of these disorders and their allergic manifestations, describe current treatment options, and discuss how providers can differentiate actinopathies from general atopy.