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Emerging Concepts in Therapeutic Interventions for Idiopathic Pulmonary Fibrosis

Cody A Schott1, Michael P Mohning2, Joseph Cooley2

  • 1Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Aurora, Colorado.

Seminars in Respiratory and Critical Care Medicine
|July 9, 2025
PubMed

Insights

Idiopathic pulmonary fibrosis (IPF) research shows promising targets but faces challenges in clinical translation. This review examines preclinical findings and the gap hindering new IPF treatments.

Area of Science:

  • Pulmonology and Respiratory Medicine
  • Translational Medicine
  • Drug Discovery and Development

Background:

  • Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with limited therapeutic options.
  • Existing treatments for IPF offer only modest benefits.
  • Preclinical research has identified numerous potential therapeutic targets for IPF.

Purpose of the Study:

  • To review the current landscape of IPF research.
  • To examine preclinical studies and their targeted pathways that have progressed to clinical trials.
  • To address the translational challenges in developing novel IPF therapies.

Main Methods:

  • Literature review of preclinical studies on IPF.
  • Analysis of IPF-related pathways and targets investigated in clinical trials.
  • Discussion of the translational gap between preclinical findings and clinical success.

Main Results:

  • Several novel pathways and targets for IPF have been identified in preclinical studies.
  • Translating these preclinical findings into successful clinical treatments for IPF has been difficult.
  • A significant gap exists between promising preclinical data and effective clinical outcomes for IPF.

Conclusions:

  • Despite extensive research, effective treatments for IPF remain limited.
  • Overcoming the translational gap is crucial for developing new IPF therapies.
  • Further research is needed to bridge the gap between preclinical promise and clinical reality for IPF treatments.

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