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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Targeting Programmed Cell Death as an Innovative Strategy Against Atherosclerosis: Potential of Natural Compound
Jilin Fan1, Tingting Zhu1, Xiaoling Tian1
1Binzhou Medical University Hospital, Binzhou, Shandong, China.
Phytotherapy Research : PTR
|July 9, 2025
Summary
Natural compounds can target programmed cell death (PCD) pathways to combat atherosclerosis (AS). This review explores how plant-derived molecules like flavonoids and polyphenols offer therapeutic potential for AS by modulating cell death mechanisms.
Area of Science:
- Biomedical Science
- Pharmacology
- Cardiovascular Research
Background:
- Atherosclerosis (AS) is a major cause of cardiovascular disease, driven by inflammation, lipid disorders, and cell death.
- Programmed cell death (PCD), including apoptosis, autophagy, pyroptosis, necroptosis, and ferroptosis, is increasingly recognized as a key factor in AS progression.
Purpose of the Study:
- To review the molecular mechanisms of critical PCD pathways in AS.
- To discuss the therapeutic potential of natural compounds targeting PCD for AS treatment and prevention.
Main Methods:
- Literature review of molecular mechanisms of PCD in AS.
- Analysis of natural products (flavonoids, polyphenols, saponins, alkaloids) and their effects on PCD pathways in AS.
Main Results:
- PCD pathways are integral to AS pathogenesis.
- Natural compounds modulate various PCD pathways to alleviate AS.
- Specific natural product classes show promise in targeting PCD for AS therapy.
Conclusions:
- Targeting PCD with natural compounds represents a promising therapeutic strategy for AS.
- Further research into these natural products can provide insights for developing precise anti-atherosclerotic therapies.
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