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Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
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[Comparative analysis of the interaction of various estrogens with the estrogen-receptor system of the uterus]
Biokhimiia (Moscow, Russia)
|November 1, 1985
Abstract:
Equilibrium binding of labeled estron, estradiol, estriol and DES was studied in uterine cytosol of immature Wistar rats. The dissociation kinetics of the ligand complexes with specific high affinity sites suggested the homogeneity of estrogen receptors in rat uterine cytosol. The feasibility of intracellular regulation of estrogen action in target cells both at the receptor and post-receptor levels is discussed.
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