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Immunotherapy in Chronic Lymphocytic Leukemia

Brian Sworder1, Tanya Siddiqi2

  • 1Division of Lymphoma, Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA.

Hematology/Oncology Clinics of North America
|July 9, 2025
PubMed

Immune-based therapies have redefined treatment strategies for a number of lymphomas including chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). This review highlights the evolution and efficacy of immune-based therapies in CLL/SLL, especially the novel monoclonal antibodies, bispecific antibodies, and chimeric antigen receptor T-cell therapy.

Keywords:
Bispecific antibodiesCAR T-cell therapyChronic lymphocytic leukemiaImmunotherapyMonoclonal antibodiesSmall lymphocytic lymphoma

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