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Related Concept Videos

Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

492
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
492

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Related Experiment Video

Updated: Sep 16, 2025

Murine Fetal Echocardiography
08:04

Murine Fetal Echocardiography

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First-Trimester Fetal Cardiac Function Measurements Using Spatio-Temporal Image Correlation and Two

K Zandbergen1, M Rousian1, Q C J Griep1

  • 1Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

Prenatal Diagnosis
|July 9, 2025
PubMed
Summary
This summary is machine-generated.

Feasibility and reproducibility of fetal cardiac ventricle volume (FCVV) measurements were assessed using two ultrasound post-processing methods. The Virtual Reality (VR) method demonstrated better feasibility and reproducibility compared to Virtual Organ Computed-Aided AnaLysis (VOCAL).

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Last Updated: Sep 16, 2025

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Area of Science:

  • Medical Imaging
  • Fetal Cardiology
  • Ultrasound Technology

Background:

  • First-trimester fetal cardiac function assessment is crucial for early detection of congenital heart defects.
  • Accurate measurement of fetal cardiac ventricle volume (FCVV) is essential for evaluating cardiac function.
  • Existing post-processing methods for ultrasound data require evaluation for feasibility and reproducibility in early pregnancy.

Purpose of the Study:

  • To evaluate the feasibility and reproducibility of two ultrasound post-processing techniques for first-trimester FCVV assessment.
  • To compare the Virtual Organ Computed-Aided AnaLysis (VOCAL) manual segmentation method with the Virtual Reality (VR) semi-automated method.
  • To assess the reliability of these methods through intra-, inter-observer, and inter-system agreement analysis.

Main Methods:

  • First-trimester transvaginal Spatio-Temporal Image Correlation (STIC) ultrasound datasets (11-14 weeks GA) were analyzed.
  • Fetal cardiac ventricle volumes (FCVV) were measured in end-diastolic (EDVV) and end-systolic (ESVV) phases using VOCAL and VR methods.
  • Reproducibility was quantified using intraclass correlation coefficients (ICCs) and Bland-Altman plots.

Main Results:

  • Both VOCAL and VR methods showed good to excellent intra- and inter-observer agreement (ICCs > 0.85).
  • Mean relative differences for FCVV measurements were generally below 10%, with an exception in VOCAL's inter-observer ESVV measurement (40.6%).
  • Inter-system agreement varied from poor to good, depending on the agreement type (absolute vs. consistency).

Conclusions:

  • Fetal cardiac ventricle volume (FCVV) measurements using the Virtual Reality (VR) method are feasible and reproducible in first-trimester STIC ultrasound datasets.
  • The VR method demonstrates superior reproducibility compared to the manual VOCAL segmentation method for FCVV assessment.
  • These findings support the use of VR for reliable early fetal cardiac function evaluation.