Mesenchymal stromal cells highly expressing Sca-1 promote breast cancer lung metastasis through recruiting myeloid cells
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View abstract on PubMed
Summary
This summary is machine-generated.Mesenchymal stem/stromal cells (MSCs) expressing high levels of stem cell antigen (Sca-1) promote lung metastasis in breast cancer. Targeting these Sca-1-high MSCs and their recruitment of macrophages may inhibit tumor spread.
Area Of Science
- Oncology
- Cell Biology
- Immunology
Background
- Mesenchymal stem/stromal cells (MSCs) are key players in the tumor microenvironment, aiding cancer cell colonization.
- Stem cell antigen (Sca-1) is a recognized surface marker for MSCs.
Purpose Of The Study
- To investigate the role of Sca-1 expression on MSCs in breast cancer lung metastasis.
- To elucidate the mechanisms by which Sca-1-high MSCs promote tumor metastasis.
Main Methods
- Comparison of Sca-1 expression in MSCs from lungs with and without tumors.
- Co-injection of 4T1 breast cancer cells with Sca-1-high and Sca-1-low MSCs.
- Analysis of chemokine expression and immune cell recruitment.
- Pharmacological inhibition of macrophage chemotaxis and use of Ccr5 knockout mice.
Main Results
- MSCs with high Sca-1 expression are associated with increased lung metastasis.
- Sca-1-high MSCs enhance tumor nodule formation and recruit 4T1 cells via CXCL1.
- Sca-1-high MSCs strongly recruit myeloid cells, particularly macrophages, to the lungs.
- Inhibiting macrophage recruitment reduces lung tumor burden.
Conclusions
- Sca-1-high MSCs promote breast cancer lung metastasis by recruiting macrophages.
- Targeting Sca-1-high MSCs and their associated effector pathways offers a potential strategy to inhibit lung metastasis.
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