Lipoprotein composition in agnogenic myeloid metaplasia

Lipoproteins have previously, been studied in various myeloproliferative disorders. This study focused only on agnogenic myeloid metaplasia (AMM). Total cholesterol (TC), phospholipids (PL) and triglycerides (TG) were measured not only in serum but also in HDL, VLDL and LDL with in the same time total apolipoproteins A1 and B. Besides hypocholesterolemia (p less than 0.01) HDL-TC were significantly diminished in mmol/l (p less than 0.01) and in percentage (p less than 0.01) while LDL.TC was decreased in mmol/l (p less than 0.01). The whole lipid moity (TC + PL + TG) of VLDL was increased (p less than 0.05). Cardiovascular diseases occur frequently in these hypocholesterolemic patients. Atherogenic ratios: LDL.TC on HDL.TC or VLDL.TC + LDL.TC on HDL.TC were not significantly higher than matching age and sex controls. Atherogenic risks could be partly related to the significant decrease of HDL.TC.