Related Experiment Video

Updated: Sep 16, 2025

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

10.1K

Allergen sensitization patterns in children with allergic rhinitis: insights from a four-year retrospective study in

Zhimin Zhao1, Liwen Chen2, Congfu Huang3

  • 1Department of Laboratory Medicine, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College), No.6, Ailong Road, Longgang District, Shenzhen, Guangdong, 518172, China.

BMC Pediatrics
|July 9, 2025
PubMed

Insights

In Shenzhen, China, children with allergic rhinitis (AR) show distinct allergen sensitization patterns. Dust mites are most common, with age and comorbidities influencing profiles, necessitating tailored diagnostics.

Area of Science:

  • Allergy and Immunology
  • Pediatrics
  • Environmental Health

Background:

  • Allergic rhinitis (AR) is a prevalent condition in children.
  • Understanding allergen sensitization is crucial for effective AR management.
  • Regional variations in allergen prevalence necessitate localized research.

Purpose of the Study:

  • To characterize allergen sensitization profiles in children with AR in Shenzhen, China.
  • To assess the influence of demographic, seasonal, and comorbidity factors on sensitization.
  • To inform region-specific diagnostic and management strategies for pediatric AR.

Main Methods:

  • Retrospective cross-sectional study of 4,279 children with AR (April 2020-March 2024).
  • Serum-specific IgE levels against 28 allergens measured by immunoblotting.
  • Statistical analysis of age, sex, season, and comorbidity influences on sensitization.

Main Results:

  • Inhaled allergen sensitization (78.3%) was more common than food allergen sensitization (65.4%).
  • Dust mites (61.6%), dog dander (21.8%), and cat dander (11.4%) were primary inhaled allergens; milk (46.9%) and egg white (27.4%) were leading food allergens.
  • Inhaled allergen sensitization increased with age, while food allergen sensitization decreased; digestive comorbidities correlated with broader sensitization.

Conclusions:

  • Distinct allergen sensitization patterns were identified in Shenzhen children with AR.
  • Findings underscore the need for region-specific diagnostic panels.
  • Integrated care approaches and personalized management are recommended for pediatric AR.
Abstract

Keywords:
Allergen profileAllergic rhinitisChildrenChinaFood allergenInhaled allergenPediatric

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

679
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.6K

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
28.8K
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
1.1K
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
983
Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
61.4K