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Updated: Aug 8, 2026

Measuring Fast Calcium Fluxes in Cardiomyocytes
Published on: November 29, 2011
[Relation of Ca2+ efflux from the heart to the concentration of Ca-channel blockers]
Abstract:
Dependence of calcium ion efflux from the heart ventricles on the concentration of verapamil, fenigidine and nicardipine was studied in frogs, using Ca-sensitive electrodes. The effect of sodium and potassium ions was also investigated. It was established that dependence of calcium ion efflux (delta Ca2+) on the concentration of Ca-antagonists (B) may be expressed by the following formula: (Formula: see text). With cellular membrane depolarization 50 mM KCl, none of the blockers (10(-5) M) caused Ca2+ efflux from ventricular cells. Analogous phenomenon was noted in low-sodium solution (60 mM).
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