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KAT6A Promotes Macrophage Inflammation and Periodontitis
Shi-Jia Huang1, Shuo Xu2,3,4,5,6, Hui-Lin Ye3,4,5,6
1Department of Orthodontics & Prosthodontics, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China.
Journal of Clinical Periodontology
|July 9, 2025
Summary
Macrophage lysine acetyltransferase 6A (KAT6A) is upregulated in periodontitis (PD). Targeting KAT6A in macrophages reduces bone loss and inflammation in PD, indicating its therapeutic potential.
Area of Science:
- Immunology
- Epigenetics
- Periodontal disease research
Background:
- Periodontitis (PD) involves epigenetic modification and immunoregulation.
- The role of macrophage lysine acetyltransferase 6A (KAT6A) in PD pathogenesis is currently unknown.
Purpose of the Study:
- To investigate the function of KAT6A in macrophages within the context of periodontitis.
Main Methods:
- Analysis of single-cell RNA sequencing data from PD patients.
- Generation of macrophage KAT6A knockout (MK6AKO) mice for PD induction models.
- RNA sequencing and Cut&tag techniques to analyze gene expression and epigenetic modifications.
Main Results:
- KAT6A was upregulated in macrophages of PD patients.
- MK6AKO mice exhibited reduced alveolar bone resorption and attenuated inflammatory gene expression post-PD induction.
- MK6AKO macrophages showed downregulated inflammatory pathways, including IL-17, and reduced histone acetylation at key inflammatory gene promoters.
Conclusions:
- KAT6A plays a significant role in modulating macrophage phenotype and driving periodontitis progression.
- Targeting KAT6A presents a potential therapeutic strategy for periodontitis.
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