A Novel Quantitative Hemodynamic Evaluation Method of Laser Therapy for Scars Based on Diffuse Correlation...

Area of Science:

• Biomedical Optics
• Medical Devices
• Laser Therapy

Background:

• Scarring affects microvascular function.
• Quantitative hemodynamic assessment is crucial for evaluating scar treatments.
• Laser therapy is a common modality for scar revision.

Purpose of the Study:

• To propose and validate a quantitative hemodynamic evaluation method for scar laser therapy using Diffuse Correlation Spectroscopy (DCS).
• To assess the feasibility of DCS in monitoring microvascular blood flow changes post-laser treatment in scars.

Main Methods:

• Development of a custom-built DCS device for in vivo measurements.
• Monitoring of microvascular blood flow (BF) and power spectral density (PSD) before and after laser therapy in six participants.
• Application of two laser therapy types: one inducing vasoconstriction, the other vasodilation.

Main Results:

• Vasoconstriction laser therapy significantly reduced scar BF by 43.27% and PSD by 72%.
• Vasodilation laser therapy significantly increased scar BF by 338.73% and PSD by 917%.
• DCS demonstrated reliable quantitative evaluation of laser therapy effects on scar hemodynamics.

Conclusions:

• DCS provides a reliable method for quantitative hemodynamic evaluation of scar laser therapy.
• The findings support the use of DCS to guide and optimize scar treatment strategies.
• DCS can assist clinicians in understanding and managing microvascular changes in scars.