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Related Experiment Video

Updated: Sep 16, 2025

Pavlovian Conditioned Approach Training in Rats
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The Signalled Licking/Avoidance of Punishment (SLAP) Paradigm in Rats: Capacity for Insight Between Goal Conditioning

Concetto Puzzo1,2,3, Maurizio Oggiano4, Micaela Capobianco3

  • 1International Telematic University Uninettuno, Rome, Italy.

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
|July 10, 2025
PubMed
Summary

Rats in a novel task learned to avoid punishment but failed to integrate learned behaviors, modeling deficits seen in children with specific learning disabilities and ADHD. This suggests a potential neurobiological basis for these cognitive impairments.

Keywords:
ADHDSLDgoal‐directed actionpassive avoidancereward

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Area of Science:

  • Neuroscience
  • Animal Behavior
  • Cognitive Psychology

Background:

  • Children with specific learning disabilities (SLD) exhibit poor logical reasoning, while those with attention-deficit/hyperactivity disorder (ADHD) show prospective memory deficits.
  • These cognitive impairments in humans present challenges in integrating learned information and executing planned actions.

Purpose of the Study:

  • To model aspects of SLD and/or ADHD in rats using the signalled-licking/avoidance-of-punishment (SLAP) protocol.
  • To assess rats' ability to merge independently learned Pavlovian and instrumental associations and deliberately exploit them.

Main Methods:

  • Rats were trained in Skinner boxes using the 'Flash' and 'Allow' paradigms within the SLAP protocol.
  • 'Flash' involved passive avoidance of footshocks during unsafe phases.
  • 'Allow' required instrumental nose-poking to access safe phases, testing goal-directed behavior.

Main Results:

  • Rats successfully learned passive avoidance in the 'Flash' paradigm.
  • In the 'Allow' paradigm, rats showed increased nose-poking but did not demonstrate instrumental exploitation of this action to control environmental phases.
  • No significant integration of independent associative learning was observed.

Conclusions:

  • The SLAP protocol effectively models passive avoidance learning but not the integration of independent associations.
  • Rats' failure to exploit nose-poking suggests a lack of understanding of instrumental control, distinct from passive avoidance.
  • The findings point to potential limbic-striatal-cortical network involvement, relevant to SLD and ADHD neurobiology.