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Updated: Sep 16, 2025
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Author Spotlight: Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration
Published on: June 9, 2023
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Intermuscular adipose tissue and muscle function in patients on maintenance hemodialysis
R Gulsah Dilaver1, Mert Demirci1, Rachelle Crescenzi2
1Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Physiological Reports
|July 10, 2025
Summary
In advanced chronic kidney disease (CKD), intermuscular adipose tissue (IMAT) is higher and linked to inflammation and reduced muscle strength. Reducing IMAT may improve outcomes for CKD patients.
Area of Science:
- Nephrology
- Muscle Physiology
- Metabolic Disorders
Background:
- Sarcopenia, a common condition in advanced chronic kidney disease (CKD), is associated with adverse patient outcomes.
- Intermuscular adipose tissue (IMAT) accumulation may negatively impact muscle function via metabolic and inflammatory mechanisms.
Purpose of the Study:
- To compare IMAT levels between patients undergoing maintenance hemodialysis (MHD) and healthy controls.
- To investigate the associations between IMAT, inflammation, metabolic markers, and muscle function in MHD patients.
Main Methods:
- A cross-sectional study involving 25 MHD patients and 23 controls.
- Calf muscle magnetic resonance imaging (MRI) was used to quantify IMAT.
- Body composition, inflammatory markers (hs-CRP, TNF-α, IL-6), insulin resistance, circulating cell-free mitochondrial DNA (ccf-mtDNA), and handgrip strength were assessed.
Main Results:
- MHD patients exhibited significantly higher IMAT compared to controls (p < 0.01).
- Elevated levels of TNF-α, IL-6, and hs-CRP were observed in MHD patients (p < 0.01).
- IMAT correlated positively with IL-6 in MHD patients and TNF-α in controls, and inversely with handgrip strength in the overall cohort (p < 0.01).
Conclusions:
- Increased IMAT is prevalent in MHD patients and associated with heightened systemic inflammation.
- IMAT may contribute to the functional decline observed in CKD.
- Targeting IMAT presents a potential therapeutic strategy for improving muscle health in CKD.
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