Cytotoxic and apoptotic effects of novel phytochemical extracts on oral squamous cell carcinoma cells

The oral squamous cell carcinoma has inadequate treatment methods. Therefore, it is of interest to investigate the effect of new phytochemical extracts on both cell death and programmed cell death of OSCC cells. The phytochemical extracts tested at different concentrations produced a decrease in cell survival which dropped from 85% to 40% (p < 0.05) and led to increased apoptotic death from 15% to 60%. Caspase-3 activation tests showed both apoptotic changes and morphological developments at the cellular level for further consideration through in vivo analysis.