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c-Abl Inhibitors in Parkinson's: Exploring Hypotheses on Alpha-Synuclein Modulation

Jyutia Nargish1, Hirok Jyoti Baishya1, Piyong Sola1

  • 1Department of Pharmacology, NETES Institute of Pharmaceutical Science, NEMCARE Group of Institutions, Shantipur, Mirza, Kamrup, Assam, India.

Advanced Pharmaceutical Bulletin
|July 10, 2025
PubMed
Summary

Parkinson's disease (PD) involves dopamine loss and alpha-synuclein aggregation. Targeting the c-Abl kinase may offer new therapeutic strategies for PD by protecting dopamine neurons and regulating alpha-synuclein.

Keywords:
NeurodegenerationParkinson’s diseasePhosphorylationc-Ablα-synuclein

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