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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Types of Fever

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Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
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Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

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Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
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Decreased Body Temperature01:29

Decreased Body Temperature

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Updated: Sep 16, 2025

Protocol for Long Duration Whole Body Hyperthermia in Mice
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Association between joint dislocation and malignant hyperthermia.

A O Gomes1, P V Andrade1, J M Santos1

  • 1Department of Neurology Federal University of São Paulo São Paulo Brazil.

Anaesthesia Reports
|July 10, 2025
PubMed
Summary
This summary is machine-generated.

Malignant hyperthermia (MH), a rare genetic disorder, is linked to a higher risk of joint dislocations. This study found 11% of MH patients experienced dislocations, compared to 0% in controls.

Keywords:
RYR1joint dislocationmalignant hyperthermiamyopathies

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Area of Science:

  • Pharmacogenetics
  • Clinical Genetics
  • Anesthesiology

Background:

  • Malignant hyperthermia (MH) is a life-threatening pharmacogenetic disorder affecting skeletal muscle calcium regulation.
  • Triggers include volatile anesthetics and succinylcholine, leading to a hypermetabolic state.
  • A potential association between MH and joint dislocations has been suggested.

Purpose of the Study:

  • To investigate the incidence of joint dislocations in patients with a history of malignant hyperthermia.
  • To determine if a correlation exists between MH susceptibility and joint dislocations.

Main Methods:

  • A standardized protocol was used to evaluate 162 patients with personal or family history of MH.
  • Comparison of joint dislocation incidence between MH-susceptible and non-susceptible individuals.

Main Results:

  • A significantly higher incidence of joint dislocations was observed in patients with malignant hyperthermia (11%) compared to non-susceptible patients (0%).
  • Statistical significance was established with p=0.002.

Conclusions:

  • This study confirms a significant association between malignant hyperthermia and joint dislocations.
  • Findings may inform clinical management strategies for MH patients, including anesthetic positioning and quality of life interventions.