Volatile organic compounds for the detection of hepatocellular carcinoma-A scoping review
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View abstract on PubMed
Summary
This summary is machine-generated.Early detection of hepatocellular carcinoma (HCC) is crucial. This review explores exhaled volatile organic compounds (VOCs) as a potential noninvasive screening tool for HCC, but standardization and large studies are needed.
Area Of Science
- Oncology
- Biochemistry
- Pulmonology
Background
- Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality with low survival rates.
- Late diagnosis limits curative treatment options for HCC, necessitating early screening methods.
Purpose Of The Study
- To critically appraise and synthesize current knowledge on using exhaled volatile organic compounds (VOCs) for noninvasive HCC detection.
- To identify advancements and challenges in VOC-based HCC screening research.
Main Methods
- A systematic electronic search was conducted for studies published up to March 24, 2023.
- Included 9 publications (2 in vitro, 7 clinical) following PRISMA guidelines.
- Analyzed data from 420 HCC patients and 630 controls across clinical studies.
Main Results
- Studies suggest a potential role for combinations of VOCs in HCC diagnosis.
- No single volatile biomarker in exhaled breath is definitively attributed to HCC.
- Significant lack of consensus and standardization exists among current studies.
Conclusions
- Exhaled VOCs show promise as a noninvasive method for HCC detection.
- Further research with large, multicenter population studies is required to validate findings.
- Standardization of methods and identification of reliable biomarkers are essential for clinical application.
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