Multifunctional Bioglues with Excellent Antibacterial Properties for Infectious Wound Healing

Bacterial infection and wound hemorrhage remain critical determinants of mortality in traumatic injuries, necessitating the development of bioglues capable of rapid hemostasis and efficient bacterial elimination. While numerous bioglues have been reported, challenges including insufficient adhesive strength, prolonged curing time, cytotoxicity, and persistent microbial contamination limit their clinical utility. Herein, a series of multifunctional bioglues are prepared via a combination of o-nitrobenzyl alcohol-modified carboxymethyl cellulose (CNC-NB), dopamine-modified carboxymethyl chitosan (CMC-DA), and antibacterial drug tobramycin (TOB). Upon irradiation by UV light, these bioglues exhibited rapid gelation behavior, outstanding bioadhesion, and hemostatic performances. Moreover, the bioglues demonstrated exceptional biocompatibility and robust antibacterial efficacy, rendering them suitable for promoting infectious wound healing. This study establishes a versatile platform for next-generation bioglues combining immediate hemostasis, antibacterial efficacy, and tissue regeneration capabilities, offering a promising alternative to conventional surgical sutures.