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Related Experiment Video

Updated: Sep 16, 2025

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
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E-Cigarette Smoke Exposure Elevates Renal MR Expression and Induces BP Elevation.

Jian Wang1,2, Bei Xu3, Ying Wang4

  • 1Department of Pediatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (J.W., R.Y.).

Hypertension (Dallas, Tex. : 1979)
|July 10, 2025
PubMed
Summary
This summary is machine-generated.

E-cigarette use with nicotine elevates blood pressure by activating the mineralocorticoid receptor (MR) in kidneys. This mechanism involves reduced 11β-HSD2 and increased pSer9GSK3β, highlighting potential renal damage from vaping.

Keywords:
11β-HSD2GSK3βblood pressuree-cigaretteeplerenonemineralocorticoid receptornicotine

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Area of Science:

  • Nephrology
  • Cardiovascular Research
  • Toxicology

Background:

  • E-cigarette use is linked to elevated blood pressure (BP), but mechanisms are unclear.
  • The mineralocorticoid receptor (MR) regulates BP and electrolyte balance.
  • The role of renal MR in e-cigarette-induced BP elevation requires investigation.

Purpose of the Study:

  • To investigate the role of the renal mineralocorticoid receptor (MR) in e-cigarette-induced blood pressure elevation.
  • To elucidate the underlying molecular mechanisms linking e-cigarette use to hypertension.

Main Methods:

  • Mice exposed to e-cigarette aerosols (with/without nicotine) and MR antagonist eplerenone.
  • Analysis of renal MR abundance, BP, urinary metabolic profiles, and key signaling pathways.
  • In vitro studies using mouse renal Cortical Collecting Duct (CCD) M1 cells.

Main Results:

  • Nicotine e-cigarettes increased renal MR, mean arterial BP, and pSer9GSK3β, while decreasing 11β-HSD2.
  • Urinary metabolic changes (elevated corticosterone/11-dehydrocorticosterone ratio, reduced sodium) and increased renal epithelial sodium channel expression were observed.
  • Eplerenone treatment normalized BP and reversed these metabolic and molecular changes.

Conclusions:

  • Aerosol nicotine from e-cigarettes induces renal MR activation, contributing to BP elevation.
  • This pathway involves reduced 11β-HSD2 and activated pSer9GSK3β in the kidneys.
  • Findings suggest potential renal health risks associated with e-cigarette use.