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Updated: Sep 16, 2025

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
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Gastrointestinal function and nutritional interventions in septic shock.

Kaspar F Bachmann1,2, Antonella Cotoia3, Annika Reintam Blaser1,4

  • 1Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland.

Current Opinion in Critical Care
|July 10, 2025
PubMed
Summary
This summary is machine-generated.

Managing gastrointestinal dysfunction in septic shock requires prioritizing hemodynamic stability and organ support. Tailored nutritional interventions, guided by patient tolerance, are crucial for recovery, moving beyond standardized calorie targets.

Keywords:
critical illnessenteral nutritiongastrointestinal dysfunctionseptic shock

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Area of Science:

  • Critical Care Medicine
  • Gastroenterology
  • Sepsis Pathophysiology

Background:

  • Gastrointestinal (GI) dysfunction is a significant complication in septic shock, affecting systemic inflammation, gut barrier integrity, and nutrient absorption.
  • Understanding the evolving role of the gut in sepsis is critical for improving patient outcomes.

Purpose of the Study:

  • To review the current understanding of GI dysfunction in septic shock.
  • To provide an updated framework for clinical management strategies.

Main Methods:

  • Systematic review of recent literature on GI dysfunction in septic shock.
  • Analysis of evolving nutritional strategies and monitoring tools.

Main Results:

  • Individualized nutritional strategies are favored over standardized calorie targets due to risks like gut ischemia and dysbiosis.
  • Maintaining splanchnic perfusion and monitoring GI tolerance are key management principles.
  • Novel therapies for gut permeability and microbiome restoration show promise but require more clinical data.

Conclusions:

  • Hemodynamic stabilization and organ support should precede nutritional goals in septic shock management.
  • Systematic GI function monitoring and tailored nutrition can prevent complications and aid recovery.
  • Further research is needed to validate monitoring tools, refine assessments, and evaluate new therapies.