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Thalamic Network Controllability Predicts Cognitive Impairment in Multiple Sclerosis.

Yuping Yang¹, Anna Woollams¹, Ilona Lipp²

¹Division of Psychology, Communication and Human Neurosciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

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|July 10, 2025

Summary

This summary is machine-generated.

Multiple sclerosis (MS) impairs the thalamus's ability to control brain network activity transitions, impacting cognitive function. This thalamic dysfunction is a key factor in cognitive impairment in MS patients.

Keywords:

cognitive impairment multiple sclerosis network controllability resting‐state fMRI subcortical network thalamus

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Area of Science:

Neuroscience
Cognitive Science
Medical Imaging

Background:

Cognitive impairment is common in multiple sclerosis (MS).
MS damages specific brain regions like the thalamus.
Altered brain network activity transitions are linked to cognitive deficits in MS.

Purpose of the Study:

To investigate how MS affects brain region controllability in driving network activity transitions.
To examine the relationship between altered controllability and cognitive impairment in MS patients.
To assess the thalamus's role in MS-related cognitive deficits.

Main Methods:

Resting-state functional MRI and neuropsychological data from MS patients and healthy controls.
Functional network controllability analysis to quantify regional influence on brain state transitions.
Replication of findings in an independent dataset.

Main Results:

MS is associated with altered controllability in the subcortical network, especially the thalamus.
Cognitively impaired MS patients showed reduced thalamic control over brain transitions.
Thalamic network controllability effectively distinguished MS from controls and predicted cognitive status.

Conclusions:

The thalamus in MS exhibits reduced capability to facilitate brain activity transitions crucial for cognitive functions.
Thalamic damage in MS disrupts network dynamics, potentially explaining cognitive impairment.
Altered thalamic controllability serves as a potential biomarker for cognitive deficits in MS.