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Published on: September 24, 2020
Myosteatosis Is Associated With Overall Survival in Patients Receiving Pancreatectomy for Pancreatic Neuroendocrine
Dan Jia1, Xiaoding Shen2,3, Ziyao Wang2,3
1Department of Outpatient, West China Hospital, Sichuan University, Chengdu, China.
Background:
To investigate the association of myosteatosis with survival among patients receiving pancreatectomy for pNETs.
Methods:
161 patients were enrolled in this retrospective cohort study. Myosteatosis was evaluated using the mean skeletal muscle attenuation with predefined cut-off values. The impact of potential risk factors on overall survival (OS) and disease-free survival (DFS) was assessed using the Kaplan-Meier method and the Cox proportional hazards model. A nomogram was constructed based on preoperative survival predictors, and its predictive performance was evaluated using the Receiver Operating Characteristic curve.
Results:
Patients with myosteatosis exhibited significantly worse OS (p = 0.003) than those without myosteatosis. However, there was no statistically significant difference in DFS between patients with myosteatosis and those without myosteatosis (p = 0.663). In univariate and multivariate analysis, after adjusting for clinicopathological factors, myosteatosis remained an independent predictor of OS (hazard ratio: 4.65; 95% confidence interval: 1.35-15.96; p = 0.02). A nomogram model, incorporating age, myosteatosis, tumor grading, and N status, demonstrated strong performance in estimating OS.
Conclusion:
Myosteatosis independently predicts OS in patients undergoing pancreatectomy for pNETs.
