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Gut microbiota: a novel strategy affecting atherosclerosis.

Lingshuang Yang1,2,3, Juan Yang3, Tiantian Zhang3

  • 1Modern Industrial College of Traditional Chinese Medicine and Health, Zhejiang Lishui Service Platform for Technological Innovations in Traditional Chinese Medicine Industry, Lishui Institute of Traditional Chinese Medicine, Lishui University, Lishui, Zhejiang, China.

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Gut microbes influence atherosclerosis, a chronic inflammatory cardiovascular disease. Altering gut microbiota composition through interventions like probiotics may offer new therapeutic strategies for this condition.

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Area of Science:

  • Cardiovascular Disease Research
  • Microbiome Studies
  • Inflammation Research

Background:

  • Atherosclerosis is a chronic inflammatory cardiovascular disease impacting arteries.
  • Gut microbiota dysbiosis, characterized by altered bacterial phyla like Firmicutes and Bacteroidetes, is linked to atherosclerosis.
  • Microbial metabolites play a significant role in the pathogenesis of atherosclerosis.

Purpose of the Study:

  • To review the intricate relationship between gut microbiota, their metabolites, and atherosclerosis.
  • To elucidate the mechanisms by which gut microbiota influence atherosclerosis at various stages.
  • To explore the potential of gut microbiota modulation as a therapeutic approach.

Main Methods:

  • Comprehensive literature review of studies on gut microbiota and atherosclerosis.
  • Analysis of research on microbial dysbiosis in cardiovascular disease patients.
  • Examination of therapeutic strategies involving gut microbiota manipulation.

Main Results:

  • Gut microbiota and their byproducts are critical factors in atherosclerosis development.
  • Specific shifts in gut microbiota composition (e.g., Firmicutes/Bacteroidetes ratio) are associated with coronary artery disease.
  • Gut microbiota influence inflammatory responses throughout all stages of atherosclerosis.

Conclusions:

  • Gut microbiota and their metabolites significantly impact atherosclerosis pathogenesis.
  • Modulating the gut microbiota through interventions like fecal microbiota transplantation (FMT), probiotics, and prebiotics presents a promising therapeutic avenue.
  • Understanding the gut microbiome's role is vital for developing novel treatments for atherosclerosis.