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Psittacosis Combined With Central Nervous System Infection and Acute Cerebral Infarction: A Case Report Based on

Shuya Tian1, Yuanyuan Xiao2, Chuanfang Dong1

  • 1Department of Geriatrics, Shandong Provincial Third Hospital, Shandong University.

The Neurologist
|July 10, 2025
PubMed
Abstract

Insights

Diagnosing psittacosis can be difficult. This case highlights psittacosis combined with central nervous system (CNS) infection and acute cerebral infarction (CI), emphasizing the utility of metagenomic next-generation sequencing (mNGS) for accurate diagnosis.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Radiology

Background:

  • Psittacosis diagnosis is challenging, often leading to underdiagnosis or misdiagnosis.
  • This report details a complex case involving psittacosis, central nervous system (CNS) infection, and acute cerebral infarction (CI).

Purpose of the Study:

  • To describe the diagnostic experience of a patient with concurrent psittacosis, CNS infection, and CI.
  • To highlight the role of metagenomic next-generation sequencing (mNGS) in diagnosing complex infectious diseases.

Main Methods:

  • A 62-year-old male presented with vertigo, progressing to fever, pneumonia, and neurological symptoms.
  • Pulmonary CT and brain MRI were used for initial imaging.
  • Metagenomic next-generation sequencing (mNGS) was crucial for confirming psittacosis and identifying Candida albicans CNS infection.
  • Conventional imaging techniques tracked the progression of cerebral infarction.

Main Results:

  • Initial presentation included vertigo and pneumonia, with subsequent development of CNS symptoms and cerebral infarction.
  • mNGS confirmed psittacosis and a concurrent Candida albicans CNS infection.
  • Brain MRI demonstrated progression of infarction in multiple cerebral regions.
  • The patient experienced severe pneumonia, respiratory failure, and ARDS.

Conclusions:

  • Psittacosis can co-occur with CNS infection and acute cerebral infarction.
  • mNGS is a valuable tool for diagnosing psittacosis and associated CNS infections.
  • Integrated diagnostic approaches combining molecular techniques and conventional imaging are essential for managing complex cases.
Keywords:
central nervous system infectionmetagenomic next-generation sequencingpsittacosis

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