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Long-Term Cardiopulmonary Function After COVID-19-Associated Acute Respiratory Distress Syndrome: A Multicenter
Fernando Luis Scolari1,2, Marciane Maria Rover1,2, Geraldine Trott1
1Escritórios de projetos, Hospital Moinhos de Vento, Porto Alegre, Brazil.
Critical Care Explorations
|July 10, 2025
Summary
Survivors of COVID-19 with acute respiratory distress syndrome (ARDS) show lasting deficits in lung function, exercise ability, and quality of life. These long-term effects persist even after recovery from critical illness.
Area of Science:
- Pulmonology
- Critical Care Medicine
- Infectious Diseases
Background:
- COVID-19 survivors, particularly those with acute respiratory distress syndrome (ARDS), may experience prolonged health issues.
- Understanding the long-term sequelae of COVID-19 ARDS is crucial for patient management and rehabilitation.
Purpose of the Study:
- To assess long-term pulmonary function in COVID-19 ARDS survivors.
- To evaluate cardiopulmonary exercise capacity, chest imaging, and health-related quality of life (HRQoL) in these survivors.
Main Methods:
- A multicentric case-control study comparing 114 COVID-19 ARDS survivors with 115 matched controls.
- Assessments included pulmonary function tests, cardiopulmonary exercise testing (CPET), chest CT scans, and HRQoL questionnaires (EQ-5D-3L) at least 12 months post-discharge.
Main Results:
- COVID-19 ARDS survivors reported persistent symptoms like fatigue and memory loss.
- Survivors showed significantly reduced diffusing capacity for carbon monoxide (DLCO) and lower peak oxygen consumption during CPET compared to controls.
- Chest CT revealed more ground-glass opacities and emphysema in survivors, who also reported lower HRQoL scores across multiple domains.
Conclusions:
- COVID-19 ARDS survivors experience significant long-term pulmonary, functional, and quality-of-life impairments.
- Abnormalities on chest CT scans are common in these survivors.
- Findings highlight the need for ongoing monitoring and targeted interventions for COVID-19 ARDS survivors.
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