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Coacervate-Based Delivery Systems: Bridging Fundamentals and Applications.
Mohammad Souri1, Wonjun Yim2, Moumita Halder1
1Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, San Diego, California 92093, United States.
ACS Applied Materials & Interfaces
|July 10, 2025
Summary
Coacervate drug delivery systems offer tunable release but face stability challenges. Molecular engineering and nanotechnology advancements are improving their therapeutic potential for targeted delivery and future innovations.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Coacervates, derived from liquid-liquid phase separation, are versatile for encapsulating diverse therapeutics.
- Stimuli-responsive properties enable precise control over drug release and targeted delivery.
- Current limitations include poor stability in biological settings and challenges in large-scale production.
Purpose of the Study:
- To review coacervate formation principles, classifications, and physicochemical properties for drug delivery.
- To examine recent advancements in formulation, nanotechnology, and computational modeling for coacervates.
- To highlight coacervate applications in gene therapy, regenerative medicine, and targeted drug delivery.
Main Methods:
- In-depth examination of coacervate formation and properties.
- Review of molecular engineering strategies for enhanced stability.
- Analysis of formulation techniques and integration with nanotechnology and computational modeling.
Main Results:
- Molecular engineering, including polyelectrolyte complexation and stimuli-responsive modifications, enhances coacervate stability and functionality.
- Integration with nanotechnology and computational modeling shows potential for improved biomedical applications.
- Coacervates demonstrate promise in gene therapy, regenerative medicine, and targeted drug delivery.
Conclusions:
- Coacervate-based systems offer significant potential for advanced therapeutic delivery, despite existing stability hurdles.
- Continued research in molecular engineering and formulation is crucial for overcoming production and stability challenges.
- Future innovations in coacervate drug delivery systems are anticipated, driven by addressing current limitations and leveraging technological advancements.
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