Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.2K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.2K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.5K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.5K
Gene Duplication and Divergence02:37

Gene Duplication and Divergence

6.3K
The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
The duplicated copies of the gene are called Paralogs. Paralogs with similar sequences and functions form a gene family. Across several species, a large number of gene families are...
6.3K
Synteny and Evolution02:31

Synteny and Evolution

3.4K
John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...
3.4K
Nucleic Acid Structure01:25

Nucleic Acid Structure

7.1K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
7.1K
Eukaryotic Evolution01:24

Eukaryotic Evolution

36.7K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
36.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Big Tau: Structure, Evolutionary Divergence, and Emerging Roles in Cytoskeletal Dynamics and Tauopathies.

Cells·2026
Same author

Analyses of exon 4a structure reveal unique properties of Big tau.

bioRxiv : the preprint server for biology·2025
Same author

Analysis of astrocyte progenitors derived from human induced pluripotent stem cells <i>in vitro</i> and following transplantation into the intact spinal cord.

bioRxiv : the preprint server for biology·2025
Same author

The unique properties of Big tau in the visual system.

Cytoskeleton (Hoboken, N.J.)·2024
Same author

Big tau: What, how, where and why.

Cytoskeleton (Hoboken, N.J.)·2023
Same author

Big Tau: What We Know, and We Need to Know.

eNeuro·2023

Related Experiment Video

Updated: Sep 16, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.5K

Perspective: Examining MAP1B Structure With an Evolutionary Perspective.

Itzhak Fischer1

  • 1Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.

Cytoskeleton (Hoboken, N.J.)
|July 10, 2025
PubMed
Summary
This summary is machine-generated.

Microtubule Associated Protein MAP1B, crucial for nervous system development, shows deep evolutionary conservation across species. This study reveals MAP1B as the most ancient member of its protein family.

More Related Videos

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

9.9K
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

15.6K

Related Experiment Videos

Last Updated: Sep 16, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.5K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

9.9K
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

15.6K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Microtubule Associated Protein MAP1B (MAP1B) is vital for nervous system development, influencing axonal growth, neuronal migration, and synapse formation.
  • MAP1B is a polyprotein processed into heavy and light chains, featuring microtubule- and actin-binding domains.

Purpose of the Study:

  • To investigate the evolutionary structure of MAP1B.
  • To identify conserved domains and potential novel functions of MAP1B across species.
  • To determine the evolutionary origin of the MAP1 family.

Main Methods:

  • Sequence analysis and alignment.
  • Exon structure determination.
  • Protein folding prediction and database searches.
  • Homolog protein identification across diverse species.

Main Results:

  • Identified key structural features and constructed a model of MAP1B.
  • Uncovered previously unrecognized, highly conserved domains within MAP1B.
  • Traced MAP1B homologs to ancient organisms like octopus and C. elegans.
  • Demonstrated that MAP1B is significantly more conserved than MAP1A and MAP1S.

Conclusions:

  • MAP1B possesses deeply conserved structural features, indicating its ancient evolutionary origins.
  • MAP1B is likely the most ancient ancestral member of the MAP1 protein family.
  • Conserved domains in MAP1B may possess novel, yet undiscovered functions.