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Updated: Sep 16, 2025
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Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
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Multicenter multiplatform pattern-of-practice analysis of single-isocenter multitarget stereotactic radiosurgery
Benedikt Thomann1,2,3,4, Tobias Fechter5,6,7,8, Johannes Fischer6,9
1Klinik für Strahlenheilkunde, Abteilung Medizinische Physik, Universitätsklinikum Freiburg, Freiburg, Germany. benedikt.thomann@uniklinik-freiburg.de.
Summary
Single-isocenter multitarget stereotactic radiosurgery (SIMT SRS) shows variability in clinical practices. This study highlights a lack of standardization in SIMT SRS, paving the way for future recommendations to ensure safe and consistent treatment delivery.
Area of Science:
- Radiation Oncology
- Medical Physics
- Radiotherapy Technology
Background:
- Single-isocenter multitarget stereotactic radiosurgery (SIMT SRS) enhances efficiency for treating multiple brain metastases.
- However, SIMT SRS presents challenges including off-center dose uncertainties, beam profile inaccuracies, and quality assurance (QA) complexities.
Purpose of the Study:
- To evaluate diverse SIMT SRS approaches by analyzing protocols and infrastructure across multiple radiotherapy centers.
- To identify areas of consensus and variability in current SIMT SRS practices.
Main Methods:
- Analysis of SIMT SRS protocols and infrastructure from 23 centers in Germany, Austria, and Switzerland.
- Assessment of immobilization, CT protocols, linear accelerators, treatment planning systems, beam configurations, imaging, and QA practices.
- Evaluation of consensus, deviations, and guideline compliance, with future plans for on-site measurements and outcome correlation.
Main Results:
- Consensus exists on CT slice thickness (≤1 mm), six-degree-of-freedom setup correction, and noncoplanar treatment.
- Significant variability observed in intrafraction imaging, planning target volume size, SRS QA, photon energy, number of fields, linear accelerators, and treatment planning systems.
Conclusions:
- Current SIMT SRS practices demonstrate a lack of standardization.
- Future research correlating protocols with treatment quality will inform recommendations for safe and standardized SIMT SRS implementation.
