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Circulating miRNAs Signature as a Predictor of Cachexia in Chronic Heart Failure: Diagnostic and Prognostic Implications

  • 0Department of Human Physiology of the Chair of Preclinical Sciences, Medical University in Lublin, Radziwillowska 11 street, 20-080, Lublin, Poland. tomaszpowrozek@gmail.com.
Journal of Cardiovascular Translational Research +

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July 10, 2025

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July 10, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

New biomarkers for cachexia in chronic heart failure (CHF) have been identified. A specific microRNA (miRNA) signature accurately predicts cachexia risk and poor survival in CHF patients.

Area Of Science

  • Biochemistry
  • Genomics
  • Cardiology

Background

  • Cachexia significantly worsens outcomes and survival in chronic heart failure (CHF) patients.
  • Early detection of cachexia is critical for improving patient prognosis.
  • Circulating microRNAs (miRNAs) are promising biomarkers linking cardiac function, inflammation, and cachexia.

Purpose Of The Study

  • To identify plasma miRNAs associated with cachexia in CHF patients.
  • To evaluate the diagnostic and prognostic value of identified miRNAs.
  • To explore the potential of miRNAs as biomarkers for nutritional status in CHF.

Main Methods

  • Plasma samples from 150 newly diagnosed CHF patients were analyzed.
  • Next-generation sequencing (NGS) was used for initial miRNA identification.
  • Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was employed for validation.

Main Results

  • A distinct miRNA signature (elevated miRNA-628 and reduced miRNA-6803) was identified and associated with cachexia.
  • This signature, combined with inflammatory markers, perfectly distinguished cachectic from non-cachectic patients (AUC=1.0).
  • The miRNA profile significantly increased cachexia risk (19-fold) and was linked to shorter survival (14 vs. 41 months).

Conclusions

  • The identified miRNA signature demonstrates strong diagnostic and predictive potential for cachexia in CHF.
  • This miRNA profile can complement clinical assessments of nutritional status in CHF patients.
  • Circulating miRNAs offer a valuable tool for early detection and risk stratification of cachexia in heart failure.

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